Photodynamic therapy is a treatment that uses a photosensitizing drug and a specific type of light to kill cancer cells and treat other conditions. The drug becomes active when exposed to a particular wavelength of light, leading to a reaction that destroys the targeted cells.

PDT is used to treat various conditions, including:

• Certain types of cancer (e.g., skin, esophageal, lung)
• Precancerous conditions like actinic keratosis
• Acne
• Psoriasis
• Age-related macular degeneration
• Infections (in some experimental treatments)

PDT involves three main components:

1. 1. Photosensitizing Agent: A drug that is injected into the target area and absorbed by cells, making them sensitive to light.
2. 2. Light Source: Specific wavelengths of light are directed at the affected area to activate the drug.
3. 3. Oxygen: The reaction between the activated drug and oxygen produces reactive oxygen species that kill the targeted cells.

Once the aminolevulinic acid solution is applied for an hour, the blue light procedure itself takes 15 minutes.

You may feel some tingling, warmth, redness and swelling up to three days post procedure. Skin can flake for up to a week.

PDT is generally well-tolerated, but some patients may experience discomfort or a burning sensation during the light activation phase. Pain management strategies can be used to minimize discomfort.

Common side effects of PDT include:

• Redness and swelling at the treatment site
• Pain or discomfort
• Crusting or blistering
• Changes in skin color (hyperpigmentation or hypopigmentation)
• Photosensitivity (sensitivity to light) for a few days to weeks after treatment

Recovery time varies depending on the treated area and the condition being treated. Most patients experience redness and swelling for a few days, with complete healing occurring within 1 to 2 weeks.

PDT is effective for treating a variety of conditions, particularly superficial cancers and precancerous lesions. The effectiveness depends on the specific condition being treated, the photosensitizing agent used, and the light source.

The number of PDT sessions required depends on the condition being treated and its severity. Some conditions may only need one session, while others may require multiple treatments over several weeks or months. A consultation with Dr. Ariel Ostad will determine how many sessions are needed for your specific treatment.

Patients should avoid direct sunlight and bright indoor lights for the first two days after treatment to prevent photosensitivity reactions. Be sure to use sunscreen until the skin is completely healed. Following the doctor’s post-treatment care instructions is crucial for optimal recovery.

PDT may not be suitable for individuals with:

• Certain types of porphyria or other photosensitivity disorders
• Pregnant or breastfeeding women (depending on the photosensitizing agent)
• Severe skin conditions or allergies to the photosensitizing agent

Yes, PDT can be combined with other treatments, such as surgery, radiation therapy, or chemotherapy, depending on the condition and the treatment plan devised by your healthcare provider.

The benefits of PDT include:

• Minimally invasive
• Targeted treatment with minimal damage to surrounding tissues
• Short recovery time
• Can be repeated multiple times if necessary